Publikationen

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2014
  1. Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia- Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte K, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T*, Lutgens E*. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. 111:2686-91, 2014 *contributed equally as senior author to the work and corresponding author   

  2. Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki I, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, and Chavakis T. Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation. Hepatology,60:1196-2010, 2014

  3. Moutsopoulos NM, Konkel J, Sarmadi M, Eskan MA, Wild T, Dutzan N, Abusleme L, Zenobia C, Hosur KB, Abe T, Uzel G, Chen W, Chavakis T, Holland SM, Hajishengallis G. Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss. Sci Transl Med. 2014 Mar 26;6:229ra40

2013

Graessler J, Bornstein TD, Goel D, Bhalla VP, Lohmann T, Wolf T, Koch M, Qin Y, Licinio J, Wong ML, Chavakis T, Xu A, Shevchenko A, Schuhmann K, Schwarz PE, Schulte KM, Patel A, Bornstein SR.
Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes.
Pharmacogenomics J.  2013 Dec 24. [Epub ahead of print] (PubMed)

Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T.
The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance.
J Immunol.  2013 Sep 16. [Epub ahead of print] (PubMed)

Chmelar J, Chung KJ, Chavakis T.
The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance.
Thromb Haemost. 2013 Jan 31. [Epub ahead of print] (PubMed)

2012

Graessler J, Qin Y, Zhong H, Zhang J, Licinio J, Wong ML, Xu A, Chavakis T, Bornstein AB, Ehrhart-Bornstein M, Lamounier-Zepter V, Lohmann T, Wolf T, Bornstein SR.
Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters.
Pharmacogenomics J. 2012 Oct 2. [Epub ahead of print] (PubMed)

Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U.
Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist.
Proc Natl Acad Sci U S A. 2012 Mar 5. [Epub ahead of print] (PubMed)

Eskan MA, Jotwani R, Abe T, Chmelar J, Lim JH, Liang S, Ciero P, Krauss J, Li F, Rauner M, Hofbauer LC, Choi EY, Chung KJ, Hashim A, Curtis M, Chavakis T*, Hajishengallis G*. 
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. 
Nature Immunology. 2012; 13: 465-473 - COVER ARTICLE *contributed equally as senior authors to the work (PubMed)

Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia. 55: 2583-92, 2012 

Hajishengallis G and Chavakis T. Endogenous modulators of inflammatory cell recruitment. Trends Immunol, 34:1-6, 2013

2002-2009

Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. 
Histone H2AX is integral to hypoxia-driven neovascularisation. 
Nature Medicine, 2009; 15:553-8 (PubMed)

Choi EY, Chavakis E, Czabanka MA, Langer H, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird W, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T. 
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. 
Science. 2008; 322:1101-04. (PubMed)

Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T. 
A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. 
EMBO J. 2007; 26:1129-39 (PubMed)

Isermann B, Vinnikov I, Madhusudhan T, Herzog S, Huntscha S, Blausitz J, Corrat M, Buender R, Zeier M, Blessing E, Chavakis T, Esmon C, Weiler H, Bierhaus A, Nawroth PP. 
The thrombomodulin protein C system protects against endothelial dysfunction and diabetic nephropathy by inhibiting glucose induced apoptosis. 
Nature Medicine, 2007; 13:1349-58 (PubMed)

Orlova V, Economopoulou M, Lupu F, Santoso S, Chavakis T. 
Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. 
J Exp Med. 2006; 203:2703-14 (PubMed)

Xie C, Alcaide P, Geisbrecht B, Schneider D, Herrmann M, Preissner KT, Luscinskas FW, Chavakis T. 
Suppression of Experimental Autoimmune Encephalomyelitis by the anti-inflammatory Extracellular Adherence Protein (Eap) of Staphylococcus aureus. 
J Exp Med 2006; 203:985-94 (PubMed)

Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner KT, Nawroth PP. 
The Pattern Recognition Receptor (RAGE) is a Counter-receptor for Leukocyte Integrins: A novel pathway for inflammatory cell recruitment. 
J. Exp. Med. 2003; 198:1507-15 (PubMed)

Santoso S, Sachs UJ, Kroll H, Linder M, Preissner KT, Chavakis T. 
The Junctional Adhesion Molecule-3 on human platelets is a counter-receptor for the leukocyte integrin Mac-1. 
J Exp Med. 2002; 196:679-691 (PubMed)

Chavakis T, Hussain M, Kanse SM, Peters G, Bretzel RG, Flock JI, Herrmann M, Preissner KT. 
Staphylococcus aureus extracellular adherence protein (Eap) serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. 
Nature Medicine. 2002; 8:687-693 (PubMed)