2017

Kemter E, Cohrs CM, Schäfer M, Schuster M, Steinmeyer K, Wolf-van Bürck L, Wolf A, Wuensch A, Kurome M, Kessler B, Zakhartchenko V, Loehn M, Ivashchenko Y, Seissler J, Schulte A, Speier S, Wolf E: INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters. Diabetologia 2017;Epub ahead of print

Cohrs CM, Chen C, Jahn SR, Stertmann J, Chmelova H, Weitz J, Bähr A, Klymiuk N, Steffen A, Ludwig B, Kamvissi V, Wolf E, Bornstein SR, Solimena M, Speier S: Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation. Endocrinology 2017;Epub ahead of print

2016

Kragl M, Schubert R, Karsjens H, Otter S, Bartosinska B, Jeruschke K, Weiss J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, Muller DJ, Lammert E: The biomechanical properties of an epithelial tissue determine the location of its vasculature. Nat Commun 2016;7:13560

Chen C, Chmelova H, Cohrs CM, Chouinard JA, Jahn SR, Stertmann J, Uphues I, Speier S: Alterations in beta-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset. Diabetes 2016;65:2676-2685

Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschop M, Machicao F, Staiger H, Haring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H: Identification of proliferative and mature beta-cells in the islets of Langerhans. Nature 2016;535:430-434

Anastasiou V, Ninou E, Alexopoulou D, Stertmann J, Muller A, Dahl A, Solimena M, Speier S, Serafimidis I, Gavalas A: Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 2016;59:139-150

2015

Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A: Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed. Arthritis Rheumatol 2015;67:903-913

Chmelova H, Cohrs CM, Chouinard JA, Petzold C, Kuhn M, Chen C, Roeder I, Kretschmer K, Speier S: Distinct roles of beta-cell mass and function during type 1 diabetes onset and remission. Diabetes 2015;64:2148-2160

2014

Marciniak A, Cohrs CM, Tsata V, Chouinard JA, Selck C, Stertmann J, Reichelt S, Rose T, Ehehalt F, Weitz J, Solimena M, Slak Rupnik M, Speier S: Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. Nat Protoc 2014;9:2809-2822

Borg DJ, Weigelt M, Wilhelm C, Gerlach M, Bickle M, Speier S, Bonifacio E, Hommel A: Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia 2014;57:522-531

2013

Marciniak A, Selck C, Friedrich B, Speier S: Mouse pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ. PLoS One 2013;8:e78706

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Muller A, Liu Y, Andree C, Mulligan B, Munster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M: Age-dependent labeling and imaging of insulin secretory granules. Diabetes 2013;62:3687-3696

Ilegems E, Dicker A, Speier S, Sharma A, Bahow A, Edlund PK, Leibiger IB, Berggren PO: Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proc Natl Acad Sci U S A 2013;110:20581-20586

2012 - 2003

Rodriguez-Diaz R, Speier S, Molano RD, Formoso A, Gans I, Abdulreda MH, Cabrera O, Molina J, Fachado A, Ricordi C, Leibiger I, Pileggi A, Berggren PO, Caicedo A: Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function. Proc Natl Acad Sci U S A 2012;109:21456-21461

15.      Speier S: Experimental approaches for high-resolution in vivo imaging of islet of Langerhans biology. Curr Diab Rep 2011;11:420-425

16.      Nyqvist D, Speier S, Rodriguez-Diaz R, Molano RD, Lipovsek S, Rupnik M, Dicker A, Ilegems E, Zahr-Akrawi E, Molina J, Lopez-Cabeza M, Villate S, Abdulreda MH, Ricordi C, Caicedo A, Pileggi A, Berggren PO: Donor islet endothelial cells in pancreatic islet revascularization. Diabetes 2011;60:2571-2577

17.      Solimena M, Speier S: Insulin release: shedding light on a complex matter. Cell Metab 2010;12:5-6

18.      Speier S, Nyqvist D, Kohler M, Caicedo A, Leibiger IB, Berggren PO: Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye. Nat Protoc 2008;3:1278-1286

Speier S, Nyqvist D, Cabrera O, Yu J, Molano RD, Pileggi A, Moede T, Kohler M, Wilbertz J, Leibiger B, Ricordi C, Leibiger IB, Caicedo A, Berggren PO: Noninvasive in vivo imaging of pancreatic islet cell biology. Nat Med 2008;14:574-578

Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Kohler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO: Glutamate is a positive autocrine signal for glucagon release. Cell Metab 2008;7:545-554

Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M: Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics. Diabetes 2007;56:1078-1086

Speier S, Yang SB, Sroka K, Rose T, Rupnik M: KATP-channels in beta-cells in tissue slices are directly modulated by millimolar ATP. Mol Cell Endocrinol 2005;230:51-58

Speier S, Rupnik M: A novel approach to in situ characterization of pancreatic beta-cells. Pflugers Arch 2003;446:553-558