Publikationen seit dem Jahr 2000

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2015
Torkko JM, Primo ME, Dirkx R, Friedrich A, Viehrig A, Vergari E, Borgonovo B, Sönmez A, Wegbrod C, Lachnit M, Münster C, Sica MP, Ermácora MR, Solimena M.
Stability and targeting of proICA512/IA-2 to insulin secretory granules requires β4-sheet mediated dimerization of its ectodomain in the endoplasmic reticulum.
Mol Cell Biol. 2015. [Epub ahead of print] (PubMed)
 
 
2014
Bornstein SR, Amiel SA, Rubino F, Mingrone G, Kamvissi V, Solimena M, Bonifacio E, Jones P, Schwarz P, Birkenfeld AL, Behrens A, Barthel A, Lechler R, Peakman M. 
Creating a "Transcampus" in Diabetes Research Between King's College London and the Technische Universität Dresden: Update on Islet Biology and Transplantation.
Horm Metab Res. 2014. [Epub ahead of print]. (PubMed) 
 
Noguera ME, Primo ME, Jakoncic J, Poskus E, Solimena M, Ermácora MR.
X-ray structure of the mature ectodomain of phogrin.
J Struct Funct Genomics. 2014. [Epub ahead of print]. (PubMed)
 
Marciniak A, Cohrs CM, Tsata V, Chouinard JA, Selck C, Stertmann J, Reichelt S, Rose T, Ehehalt F, Weitz J, Solimena M, Slak Rupnik M, Speier S.
Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology.
Nat Protoc. 2014; 9(12):2809-22. (PubMed)
 
Knoch KP, Nath-Sain S, Petzold A, Schneider H, Beck M, Wegbrod C, Sönmez A, Münster C, Friedrich A, Roivainen M, Solimena M.
PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells.
Mol Metab. 2014; 14;3(5):518-30. (PubMed)

 

 

2013

Magro MG, Solimena M.
Regulation of beta cell function by RNA-binding proteins.
Mol Met. 2013; 2(4):348-55. (PubMed)

Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR.
Transplantation of human islets without immunosuppression.
Proc Natl Acad Sci U S A. 2013; 110(47):19054-8. (PubMed)

Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T.
The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance.
J Immunol. 2013; 191(8):4367-74. (PubMed)

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y, Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M.
Age-dependent labeling and imaging of insulin secretory granules. 
Diabetes. 2013; 62(11):3687-96. (PubMed)

Krautz C, Wolk S, Steffen A, Knoch KP, Ceglarek U, Thiery J, Bornstein S, Saeger HD, Solimena M, Kersting S.
Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets.
Diabetologia. 2013; 56(7):1596-604. (PubMed)

Sturm D, Marselli L, Ehehalt F, Richter D, Distler M, Kersting S, Grützmann R, Bokvist K, Froguel P, Liechti R, Jörns A, Meda P, Baretton GB, Saeger HD, Schulte AM, Marchetti P, Solimena M.
Improved protocol for laser microdissection of human pancreatic islets from surgical specimens.
J Vis Exp. 2013 Jan 6;(71). (PubMed)

2012

Heni M, Ketterer C, Wagner R, Linder K, Böhm A, Herzberg-Schäfer SA, Machicao F, Knoch KP, Fritsche A, Staiger H, Häring HU, Solimena M.
Polymorphism rs11085226 in the gene encoding Polypyrimidine-tract binding protein 1 negatively affects glucose-stimulated insulin secretion.
PLoS One. 7, e46154 (PubMed)

Dirkx R Jr, Solimena M.
Cholesterol-enriched membrane rafts and insulin secretion.
J Diabet Invest. 3: 339-346.

Bonner SM, Pietropaolo SL, Fan Y, Chang Y, Sethupathy P, Morran MP, Beems M, Giannoukakis N, Trucco G, Palumbo MO, Solimena M, Pugliese A, Polychronakos C, Trucco M, Pietropaolo M.
Sequence variation in the promoter of the Ica1 gene, which encodes a protein implicated in type 1 diabetes, causes the transcription factor AIRE to increase its binding and downregulate expression.
J Biol Chem. 287: 17882-17893 (PubMed)

Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M.
Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.
Diabetologia. 55: 1013-1023 (PubMed)

2011

Primo ME, Jakoncic J, Noguera ME, Risso VA, Sosa L, Sica MP, Solimena M, Poskus E, Ermácora MR.
Protein-protein interactions in crystals of  the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.
PLoS One. 6: e24191 (PubMed)

Bötticher G, Sturm D, Ehehalt F, Knoch KP,  Kersting S, Grützmann R, Baretton GB, Solimena M, Saeger HD.
Isolation of Human Islets from Partially Pancreatectomized Patients.
J Vis Exp. 2011 Jul 30;(53). (PubMed)

Steffen A, Ludwig B, Krautz C, Bornstein S, Solimena M.
Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry.
Islets. 3 (PubMed)

Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, Stewart AF, Solimena M.
PTBP1 is required for embryonic development before gastrulation.
PLoS One. 6: e16992 (PubMed)

Geis C, Weishaupt A, Grünewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C.
Human stiff-person syndrome IgG induces anxious behavior in rats.
PLoS One. 6: e16775 (PubMed)

2010

Ehehalt F, Knoch K, Erdmann K, Krautz C, Jäger M, Steffen A, Wegbrod C, Meisterfeld R, Kersting S, Bergert H, Kuhlisch E, Bornstein S, Bonifacio E, Saeger HD, Solimena M.
Impaired insulin turnover in islets from type 2 diabetic patients.
Islets. 2:30-36 (PubMed)

Liu Y, Suckale J, Masjkur J, Magro MG, Steffen A, Anastassiadis K, Solimena M.
Tamoxifen-independent recombination in the RIP-CreER mouse.
PLoS One. 5:e13533 (PubMed)

Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M.
β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules.
PLoS One. 5:e12929 (PubMed)

Solimena M, Speier S.
Insulin release: shedding light on a complex matter.
Cell Metab. 12:5-6 (PubMed)

Suckale J, Solimena M.
The insulin secretory granule as a signaling hub.
Trends Endocrinol Metab. 21:599-609 (PubMed)

Ries J, Bayer M, Csúcs G, Dirkx R, Solimena M, Ewers H, Schwille P.
Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy.
Opt Express. 18:11073-11082 (PubMed)

2009

Liu Y, Mziaut H, Ivanova A, Solimena M.
beta-Cells at the crossroads: choosing between insulin granule production and proliferation.
Diabetes Obes Metab. 11 Suppl 4: 54-64. (PubMed)

Reimann M, Bonifacio E, Solimena M, Schwarz PE, Ludwig B, Hanefeld M, Bornstein SR.
An update on preventive and regenerative therapies in diabetes mellitus.
Pharmacol Ther. 121: 317-331. (PubMed)

2008

Suess C, Czupalla C, Winter C, Pursche T, Knoch KP, Schroeder M, Hoflack B, Solimena M.
Rapid changes of mRNA binding protein levels following glucose and IBMX stimulation of insulinoma INS-1 cells.
Mol Cell Proteomics. 2008; 8: 393-408. (PubMed)

Suess C, Solimena M.
Proteomic profiling of b-cells using a classical approach two-dimensional gel electrophoresis.
Exp Clin Endocrinol Diabetes. 2008; 116 Suppl 1: S13-20. (PubMed)

Trajkovski M, Mziaut H, Schubert S, Kalaidzidis Y, Altkrüger A, Solimena M.
Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.
J Biol Chem. 2008; 283: 33719-29. (PubMed)

Suckale J, Solimena M.
Pancreas islets in metabolic signaling
Front Biosci. 2008; 13: 7156-71. (PubMed)

Meisterfeld R, Ehehalt F, Saeger HD, Solimena M.
Pancreatic disorders and diabetes mellitus.
Exp Clin Endocrinol Diabetes. 2008; 116 Suppl 1: S7-S12. (PubMed)

Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M.
ICA512 signaling enhances panreatic β-cell proliferation by regulating cyclins D through STATs.
Proc Natl Acad Sci USA. 2008; 105: 674-9. (PubMed)

Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Eur J Cell Biol. 2008; 87: 197-209. (PubMed)

2007

Ehninger A, Mziaut H, Solimena M.
Emerging role of SUMO in pancreatic β-cells.
Horm Metab Res. 2007; 39: 658-64. (PubMed)

2006

Borgonovo B, Ouwendijk J, Solimena M.
Biogenesis of secretory granules.
Curr Opin Cell Biol 2006; 18: 365-370 (PubMed)

Trajkovski M, Mziaut H, Schwarz PE, Solimena M.
Genes of type 2 diabetes in Beta cells.
Endocrinol Metab Clin North Am. 2006; 35: 357-369 (PubMed)

Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkruger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Muller S, Solimena M.
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.
Nat Cell Biol. 2006; 8: 435-445 (PubMed)

Knoch KP, Meisterfeld R, Kersting S, Bergert H, Altkruger A, Wegbrod C, Jager M, Saeger HD, Solimena M.
cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells.
Cell Metabol. 2006; 3: 123-134 (PubMed)

2005

Bergert H, Knoch KP, Meisterfeld R, Jager M, Ouwendijk J, Kersting S, Saeger HD, Solimena M.
Effect of oxygenated perfluorocarbons on isolated rat pancreatic islets in culture.
Cell Transplant. 2005; 14: 441-448 (PubMed)

Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M.
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.
J Cell Biol. 2005 Aug 15; 170: 607-618 (PubMed)

2004

Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S, Solimena M.
Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells.
J Cell Biol. 2004 Dec 20; 167: 1063-1074 (PubMed)

Yang Y, Lacas-Gervais S, Morest DK, Solimena M, Rasband M.
βIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.
J Neurosci. 2004 Aug 18; 24(33): 7230-7240. (PubMed)

Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, Solimena M.
Markedly elevated GAD antibodies in SPS: effects of age and illness duration.
Neurology Neurology. 2004 Dec 14; 63(11): 2146-2148. (PubMed) 

Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, De Camilli P, Moser T, Rasband M, Solimena M.
βIVΣ1 spectrin stabilizes nodes of Ranvier and axon initial segments.
J Cell Biol 2004 Sep 27; 166(7): 983-990. (PubMed)

Knoch KP, Bergert H, Borgonovo B, Saeger H.-D., Altkrüger A, Verkade P, Solimena M.
Polypyrimidine tract binding protein promotes insulin secretory granule biogenesis.
Nat Cell Biol. 2004 Mar; 6(3): 207-214. (PubMed)

Petzold GC, Marcucci M, Butler MH, van Landeghem FKH, Scholz P, Einhäupl KM, Solimena M, Valdueza JM, De Camilli P.
Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity.
Ann. Neurol. 2004 Feb; 55: 286-290. (PubMed)

2003

Solimena M and Gerdes H-H.
Secretory granules: and the last shall be first....
Trends Cell Biol. 2003 Aug; 13: 399-402. (PubMed)

Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M.
Islet Cell Autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.
J. Biol. Chem. 2003 Jul 11; 278: 26166-26173. (PubMed)

2002

Schmierer K, Grosse P, De Camilli P, Solimena M, Floyd S, Zschenderlein R.
Paraneoplastic stiff-person syndrome- no tumor progression over five years.
Neurology. 2002 Jan 8; 58: 148. (PubMed)

2001

Ort T, Voronov S, Guo J, Zawalich K, Froehner S, Zawalich W, Solimena M.
Dephosphorylation of β-2 syntrophin and Ca2+/calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.
EMBO J. 2001 Aug 1; 20:4013-4023. (PubMed)

Meinck H-M, Maile S, Faber L, Morgenthaler N, Seissler J, Butler M, Solimena M, DeCamilli P, Scherbaum WA. 2001.
Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases.
J. Neurol. Neurosurg. Psych. 2001 Jul; 71:100-103. (PubMed)

Berghs S, Ferracci F, Maksimova E, Gleason S, Leszczynski N, Butler M, De Camilli P, Solimena M.
Autoimmunity against β-IV-spectrin in paraneoplastic motor neuron syndrome. Proc Natl Acad Sci USA. 2001 Jun 5; 98: 6945-6950. (PubMed)

2000

Solimena M and De Camilli, P.
Synaptic autoimmunity and the Salk factor.
Neuron. 2000 Nov; 28: 309-310. (PubMed)

Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel J-H, Zhang J-P, W. Philbrick W., Slepnev V, Ort T, Solimena M.
βIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system.
J. Cell Biol. 2000 Nov 27; 151: 985-1002. (PubMed)

Ort T, Maksimova E, Dirkx R, Kachinsky A, Berghs S, Froehner S, Solimena M.
The receptor tyrosine phosphatase like-protein ICA512 binds the PDZ domains of β2-syntrophin and nNOS in pancreatic β-cells.
Eur. J. Cell Biol. 2000 Sep; 79: 621-630. (PubMed)

Butler MH, Hayashi A, Ohkoshi N, Villman C, Beckerle C-M, Feng G, De Camilli P, Solimena M.
Autoimmunity to gephyrin in stiff-man syndrome.
Neuron. 2000 May; 26: 307-312. (PubMed)