Publikationen seit dem Jahr 2009

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2014

Endesfelder D, Zu Castell W, Ardissone A, Davis-Richardson AG, Achenbach P, Hagen M, Pflueger M, Gano KA, Fagen JR, Drew JC, Brown CT, Kolaczkowski B, Atkinson M, Schatz D, Bonifacio E, Triplett EW, Ziegler AG.
Compromised gut microbiota networks in children with anti-islet cell autoimmunity.
Diabetes. 2014 Mar 7.  [Epub ahead of print] (PubMed)

Krause S, Landherr U, Agardh CD, Hausmann S, Link K, Hansen JM, Lynch KF, Powell M, Furmaniak J, Rees-Smith B, Bonifacio E, Ziegler AG, Lernmark A, Achenbach P.
GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial.
Diabetes Care. 2014 Mar 5. 
[Epub ahead of print] (PubMed)

Ferreira RC, Guo H, Coulson RM, Smyth DJ, Pekalski ML, Burren OS, Cutler AJ, Doecke JD, Flint S, McKinney EF, Lyons PA, Smith KG, Achenbach P, Beyerlein A, Dunger DB, Wicker LS, Todd JA, Bonifacio E, Wallace C, Ziegler AG.
A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes.
Diabetes. 2014 Feb 21. [Epub ahead of print] (PubMed)

Stumpp C, Beyerlein A, Ziegler AG, Bonifacio E.
Neonatal and infant beta cell hormone concentrations in relation to type 1 diabetes risk.
Pediatr Diabetes. 2014 Feb 19. [Epub ahead of print] (PubMed)

 

2013

 

Borg DJ, Weigelt M, Wilhelm C, Gerlach M, Bickle M, Speier S, Bonifacio E, Hommel A.
Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model.
Diabetologia. 2013 Nov 20. [Epub ahead of print] (PubMed)

Bonifacio E, Krumsiek J, Winkler C, Theis FJ, Ziegler AG.
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.
Acta Diabetol. 2013 Nov 19. [Epub ahead of print] (PubMed)

Eugster A, Lindner A, Heninger AK, Wilhelm C, Dietz S, Catani M, Ziegler AG,Bonifacio E. 
Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells. 
J Immunol Methods. 2013  Nov 13. [Epub ahead of print] (PubMed)

Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR.

Transplantation of human islets without immunosuppression.
Proc Natl Acad Sci U S A. 2013 Oct 28. [Epub ahead of print](PubMed)

Krause S, Beyerlein A, Winkler C, Gavrisan A, Kayser C, Puff R, Bonifacio E, Ziegler AG, Achenbach P.
Soluble interleukin-2 receptor alpha in preclinical type 1 diabetes. 
Acta Diabetol. 2013 Sep 5. [Epub ahead of print] (PubMed)

Ringers J, van der Torren CR, van de Linde P, van der Boog PJ, Mallat MJ,Bonifacio E, Roep BO, de Fijter JW.
Pretransplantation GAD-autoantibody status to guide prophylactic antibody induction therapy in simultaneous pancreas and kidney transplantation.
Transplantation. 2013 Oct 27. (PubMed)

Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, Winkler C, Ilonen J, Veijola R, Knip M, Bonifacio E, Eisenbarth GS. 
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. 
JAMA. 2013 Jun 1. (PubMed)

Lee HS, Briese T, Winkler C, Rewers M, Bonifacio E, Hyoty H, Pflueger M, Simell O, She JX, Hagopian W, Lernmark A, Akolkar B, Krischer JP, Ziegler AG; TEDDY study group.
Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes.
Diabetologia. 2013 May 9. [Epub ahead of print] (PubMed)

Bonifacio E. 
Targeting innate immunity in type 1 diabetes: strike one.
Lancet. 2013 Apr 4. [Epub ahead of print] (PubMed)

Monti P, Brigatti C, Krasmann M, Ziegler AG, Bonifacio E. 
Concentration and activity of the soluble form of the Interleukin-7 Receptor alpha in type I diabetes identifies an interplay between hyperglycemia and immune function.
Diabetes. 2013 Mar 1. [Epub ahead of print] (PubMed)

Maliga Z, Junqueira M, Toyoda Y, Ettinger A, Mora-Bermúdez F, Klemm RW, Vasilj A, Guhr E, Ibarlucea-Benitez I, Poser I, Bonifacio E, Huttner WB, Shevchenko A, Hyman AA. 
A genomic toolkit to investigate kinesin and myosin motor function in cells.
Nat Cell Biol. 2013; 15, 325-34 (PubMed)

Heninger AK, Monti P, Wilhelm C, Schwaiger P, Kuehn D, Ziegler AG, Bonifacio E. 
Activation of islet autoreactive naive T cells in infants is influenced by homeostatic mechanisms and antigen presenting capacity.
Diabetes. 2013 Jan 24. [Epub ahead of print] (PubMed)

Piemonti L, Everly MJ, Maffi P, Scavini M, Poli F, Nano R, Cardillo M, Melzi R, Mercalli A, Sordi V, Lampasona V, Espadas de Arias A, Scalamogna M, Bosi E, Bonifacio E, Secchi A, Terasaki PI. 
Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes.
Diabetes. 2013; 62, 1656-64 (PubMed)

2012

Heninger AK, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K, Bonifacio E, Monti P.
IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells.
J Immunol. 2012; 189, 5649-58 (PubMed)

Krause S, Chmiel R, Bonifacio E, Scholz M, Powell M, Furmaniak J, Rees Smith B, Ziegler AG, Achenbach P. 
IA-2 autoantibody affinity in children at risk for type 1 diabetes.
Clin Immunol. 2012; 145, 224-9 (PubMed)

Citro A, Cantarelli E, Maffi P, Nano R, Melzi R, Mercalli A, Dugnani E, Sordi V, Magistretti P, Daffonchio L, Ruffini PA, Allegretti M, Secchi A, Bonifacio E, Piemonti L.
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.
J Clin Invest. 2012; 122, 3647-51 (PubMed)

Bonifacio E. 
Immunotherapy in type 1 diabetes: a shorter but more winding road?
Diabetes. 2012; 61, 2214-5 (PubMed)

Fuchs YF, Adler K, Bonifacio E. 
Beta-cell autoimmunity.
Methods Mol Biol. 2012; 933, 265-74 (PubMed)

Baxter J, Vehik K, Johnson SB, Lernmark B, Roth R, Simell T; TEDDY Study Group (2012)
Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study.
Contemp Clin Trials. 2012; 33, 633-40 (PubMed)

Ziegler AG, Meier-Stiegen F, Winkler C, Bonifacio E; TEENDIAB Study Group 2012)
Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty--TEENDIAB: study design.
Pediatr Diabetes. 2012; 13, 419-24 (PubMed)

2011

Bonifacio E, Warncke K, Winkler C, Wallner M, Ziegler AG.
Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk.
Diabetes. 2011; 60, 3300-6 (PubMed)

Pflueger M, Seppänen-Laakso T, Suortti T, Hyötyläinen T, Achenbach P, Bonifacio E, Orešič M, Ziegler AG. 
Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes.
Diabetes. 2011; 60, 2740-7 (PubMed)

Ferraro A, Socci C, Stabilini A, Valle A, Monti P, Piemonti L, Nano R, Olek S, Maffi P, Scavini M, Secchi A, Staudacher C, Bonifacio E, Battaglia M.
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes.
Diabetes. 2011; 60, 2903-13 (PubMed)

Borg DJ, Bonifacio E. 
The use of biomaterials in islet transplantation.
Curr Diab Rep. 2011; 11, 434-44 (PubMed)

Hagopian WA, Erlich H, Lernmark A, Rewers M, Ziegler AG, Simell O, Akolkar B, Vogt R Jr, Blair A, Ilonen J, Krischer J, She J; TEDDY Study Group. 
The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants.
Pediatr Diabetes. 2011; 12, 733-43 (PubMed)

Hummel S, Pflüger M, Hummel M, Bonifacio E, Ziegler AG.
Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study.
Diabetes Care. 2011; 34, 1301-5 (PubMed)

Ziegler AG, Pflueger M, Winkler C, Achenbach P, Akolkar B, Krischer JP, Bonifacio E.
Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children.
J Autoimmun. 2011; 37, 3-7 (PubMed)

Winkler C, Lauber C, Adler K, Grallert H, Illig T, Ziegler AG, Bonifacio E.
An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.
Diabetes. 2011; 60, 685-90 (PubMed)

2010

Thümer L, Adler K, Bonifacio E, Hofmann F, Keller M, Milz C, Munte A, Ziegler AG. 
German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results.
Rev Diabet Stud. 2010; 7, 202-8 (PubMed)

Ehehalt F, Knoch K, Erdmann K, Krautz C, Jäger M, Steffen A, Wegbrod C, Meisterfeld R, Kersting S, Bergert H, Kuhlisch E, Bornstein S, Bonifacio E, Saeger HD, Solimena M.
Impaired insulin turnover in islets from type 2 diabetic patients.
Islets. 2010; 2, 30-6 (PubMed)

Achenbach P, Guo LH, Gick C, Adler K, Krause S, Bonifacio E, Colman PG, Ziegler AG. 
A simplified method to assess affinity of insulin autoantibodies.
Clin Immunol. 2010; 137, 415-21 (PubMed)

Bonifacio E, Ziegler AG.
Advances in the prediction and natural history of type 1 diabetes.
Endocrinol Metab Clin North Am. 2010; 39, 513-25 (PubMed)

Melzi R, Mercalli A, Sordi V, Cantarelli E, Nano R, Maffi P, Sitia G, Guidotti LG, Secchi A, Bonifacio E, Piemonti L.
Role of CCL2/MCP-1 in islet transplantation.
Cell Transplant. 2010; 19, 1031-46 (PubMed)

Winkler C, Bonifacio E, Grallert H, Henneberger L, Illig T, Ziegler AG. 
BMI at age 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1.
Diabetes. 2010; 59, 2063-7 (PubMed)

Bonifacio E, Yu L, Williams AK, Eisenbarth GS, Bingley PJ, Marcovina SM, Adler K, Ziegler AG, Mueller PW, Schatz DA, Krischer JP, Steffes MW, Akolkar B. 
Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia.
J Clin Endocrinol Metab. 2010; 95, 3360-7 (PubMed)

Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, Galli R, Sordi V, Bosi E, Martino G, Bonifacio E, Doglioni C, Piemonti L.
Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice.
PLoS One. 2010; 5, e10357 (PubMed)

Walter M, Kaupper T, Adler K, Foersch J, Bonifacio E, Ziegler AG. 
No effect of the 1alpha,25-dihydroxyvitamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes.
Diabetes Care. 2010; 33, 1443-8 (PubMed)

Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C, Tiboni F, Ferrari G, Nano R, Chwalek K, Lammert E, Bonifacio E, Borg D, Piemonti L.
Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.
Stem Cells. 2010; 28, 140-51 (PubMed)

Lampasona V, Petrone A, Tiberti C, Capizzi M, Spoletini M, di Pietro S, Songini M, Bonicchio S, Giorgino F, Bonifacio, E, Bosi E, Buzzetti R; Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study Group. 
Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4.
Diabetes Care. 2010; 33, 104-8 (PubMed)

2009

Melzi R, Maffi P, Nano R, Sordi V, Mercalli A, Scavini M, Secchi A, Bonifacio E, Piemonti L. 
Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans.
Islets. 2009; 1, 42-9 (PubMed)

Williams AJ, Somerville M, Rokni S, Bonifacio E, Yu L, Eisenbarth G, Akolkar B, Steffes M, Bingley PJ. 
Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility.
J Immunol Methods. 2009; 351, 75-9 (PubMed)

Cantarelli E, Melzi R, Mercalli A, Sordi V, Ferrari G, Lederer CW, Mrak E, Rubinacci A, Ponzoni M, Sitia G, Guidotti LG, Bonifacio E, Piemonti L. 
Bone marrow as an alternative site for islet transplantation.
Blood. 2009; 114, 4566-74 (PubMed)

Winkler C, Illig T, Koczwara K, Bonifacio E, Ziegler AG.
HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.
J Clin Endocrinol Metab. 2009; 94, 4113-5 (PubMed)

Mueller DB, Koczwara K, Mueller AS, Pallauf J, Ziegler AG, Bonifacio E.
Influence of early nutritional components on the development of murine autoimmune diabetes.
Ann Nutr Metab. 2009; 54, 208-17 (PubMed)

Monti P, Heninger AK, Bonifacio E.
Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus.
Curr Diab Rep. 2009; 9, 113-8 (PubMed)